Filtered Kombucha Tea Rings the Bell for TLR2, TLR4, MYD88, and Dectin-1 in Mice Model of Colitis

نویسندگان

  • Amin Gharanfoli Student Research Committee, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
  • Elaheh Mahmoudi* Division of Mycology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
  • Mansoureh Yazdkhasti Department of Midwifery, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
چکیده مقاله:

Background and objectives: TLR2, TLR4, and Dectin-1 (Clec7) are pattern recognition receptors (PRRs) expressed by intestinal epithelia cells and MYD88 is a signaling molecule of TLR2 and TLR4.  They warn immune system about the presence of invading pathogens promoting initiation of inflammatory response. Because of colonic cancer risk, therapy of intestinal inflammation is of high importance. Natural products are suitable candidates among which Kombucha tea has shown healing effect on mice model of colitis. Methods: Filtered Kombucha tea was prepared from black tea and sucrose plus tea fungus and previously fermented Kombucha tea. The collection was fermented by incubation at 28 °C for 14 days and filtered. Colitis was induced in young and old mice by administration of 3.5% (w/v) dextran sodium sulfate in drinking water during 7 days; filtrated Kombucha tea was given orally to animals with colitis, at a dose volume of 10 mL/kg daily for 21 days. Dectin-1, f toll-like receptor (TLR)-2, 4, as PRRs, and MyD88, as PRR signaling molecule were measured and compared with the age-matched normal and colitis model. Results: Treatment with filtrated Kombucha tea significantly affected TLR2/TLR4 pathway and its downstream signaling molecules, MYD88 & dectin-1expression and subsequently inflammatory condition in dextran sodium sulfate-induced colitis. Conclusion:  The results of the present study may indicate possible implication of Kombucha tea with TLRS which consequently produces the anti-colitis effects.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Filtered Kombucha tea ameliorates the leaky gut syndrome in young and old mice model of colitis

Objective(s): Zonula occludens proteins (ZO-1 and ZO-2) are important intracellular tight junction (TJ)-associated proteins that link the cell cytoskeleton to the trans-membrane TJ proteins.  Destruction of TJ proteins is called the “leaky gut syndrome” and has been observed in some of the gastrointestinal diseases such as the inflammatory bowel disease (IBD). So, ther...

متن کامل

the use of appropriate madm model for ranking the vendors of mci equipments using fuzzy approach

abstract nowadays, the science of decision making has been paid to more attention due to the complexity of the problems of suppliers selection. as known, one of the efficient tools in economic and human resources development is the extension of communication networks in developing countries. so, the proper selection of suppliers of tc equipments is of concern very much. in this study, a ...

15 صفحه اول

the innovation of a statistical model to estimate dependable rainfall (dr) and develop it for determination and classification of drought and wet years of iran

آب حاصل از بارش منبع تأمین نیازهای بی شمار جانداران به ویژه انسان است و هرگونه کاهش در کم و کیف آن مستقیماً حیات موجودات زنده را تحت تأثیر منفی قرار می دهد. نوسان سال به سال بارش از ویژگی های اساسی و بسیار مهم بارش های سالانه ایران محسوب می شود که آثار زیان بار آن در تمام عرصه های اقتصادی، اجتماعی و حتی سیاسی- امنیتی به نحوی منعکس می شود. چون میزان آب ناشی از بارش یکی از مولفه های اصلی برنامه ...

15 صفحه اول

The effect of one course circuit resistance training with different intensity on the levels of Myd88, TLR2 and TLR4 in obese postmenopausal women

Introduction: Tol-like receptors (TLRs) play an important role in inducing inflammatory insulin resistance, and modulating their levels is effective in improving insulin resistance. The aim of this study was to evaluate the effect of one course circuit resistance training with different intensity on the levels of Myd88, TLR2 and TLR4 in obese postmenopausal women. Method: 44 postmenopausal wom...

متن کامل

the search for the self in becketts theatre: waiting for godot and endgame

this thesis is based upon the works of samuel beckett. one of the greatest writers of contemporary literature. here, i have tried to focus on one of the main themes in becketts works: the search for the real "me" or the real self, which is not only a problem to be solved for beckett man but also for each of us. i have tried to show becketts techniques in approaching this unattainable goal, base...

15 صفحه اول

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


عنوان ژورنال

دوره 7  شماره 3

صفحات  1- 4

تاریخ انتشار 2020-07-01

با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.

کلمات کلیدی

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023